Структурные и функциональные особенности IgA1-протеаз

This review is dedicated to structural and functional properties of IgA1-proteases in pathogenic microorganisms. The interest to structural and functional studies of IgA-proteases is caused essentially by their putatively great impact on set up and progression of infectious diseases. IgA degradation at mucosal surfaces is commonly suggested to be the main function of IgA1-proteases. In turn, this effect may lead to abatement of the immune response efficiency at the epithelial barrier. In our review, structural comparison of “classic” IgA1-proteases with their functional analogues and structural homologues allows to hypothesize IgA-protease dependent effector mechanisms mediated by serum IgA.