One stop screening for multiple cancers: The experience of an integrated cancer prevention center

Abstract Background Cancer is a leading cause of mortality worldwide. Screening is a key strategy for reducing cancer morbidity and mortality. Methods We aimed to describe the experience of an integrated cancer prevention center in screening an asymptomatic population for the presence of neoplasia. One-thousand consecutive asymptomatic, apparently healthy adults, aged 20–80 years, were screened for early detection of 11 common cancers that account for 70–80% of cancer mortality. Results Malignant and benign lesions were found in 2.4% and 7.1% of the screenees, respectively. The most common malignant lesions were in the gastrointestinal tract and breast followed by gynecological and skin. The compliance rate for the different screening procedures was considerably higher than the actual screening rate in the general Israeli population — 78% compared to 60% for mammography (p  APC and CD24 genes indicated high cancer risk. When two of the polymorphisms existed in an individual, the risk for a neoplastic lesion was extremely high (OR 2.3 [95% CI 0.94–5.9]). Conclusions One stop shop screening for 11 common cancers in the setting of a multidisciplinary outpatient clinic is feasible and can detect cancer at an early stage.