Biological Clock: Serum Melatonin in Hypertension.

To study the significance of serum melatonin level in essential hypertensive patients compared with age and sex matched healthy controls. Case control Study conducted at Sree Balaji Medical College & Hospital. Total number of people recruited in the study was 100. Of which, 50 are essential hypertensive patients and 50 are healthy controls. It was estimated by Melatonin ELISA KIT - Quantitative sandwich enzyme immunoassay technique. Serum melatonin levels was found to be significantly low in hypertensives compared to healthy controls with significant p value (0.001). In our study, significant reduction of melatonin levels is obseved in hypertensives when compared with normotensives.The reduced melatonin level in hypertensives may lead to the risk of developing cardiovascular complication insisting prompt control of blood pressure.