Prognostic importance of pre-operative CEA and CA 19-9 levels in gastric carcinoma

was 68.8 months We made serial sections from formalm-fk,ved and paraffin embedded blocks, and perihuned H-E staming and itntnunohtstochemical staining for c-met. We classified the expression of c-met at the invasive front were evaluated as positive (+ ) or negative (--). The finding of budding at the invasive front was recorded according to Morodomi cnteria. Results The expression ot c-met was 37 lesions and was significantly correlated with budding, lymphatic invasion, lympMode metastasis, recurrence and progmosis. Budding was observed in 49 lesions and was also significantly correlated with lymphnode metastasis, recurrence and prognosis On the other hand the expression of c-met was closely associated with budding Muluvanate proportional hazard model revealed that the expression of c-met was the only significant co-factor of postoperative survival in pT3 colon cancer Conclusion To predict recurrence and prognosis, it is usefnl to investigated tile expression of c-met. Thus, this resnh suggests (hat stage II patients with c-met positive lesions should received postoperative adiuvant therapy even m the absence of lyrnphnode metastasis