A four-year history of pruriginous erythroderma leading to the diagnosis of idiopathic hypereosinophilic syndrome.

spontaneous healing a few weeks after withdrawal of REFERENCES the drug (1, 2). 1. Schlienger RG, Shear NH. Antiepileptic drug hyperAn essential issue to take into account in these patients œsensitivity syndrome. Epilepsia 2000; 39: S3–7. is the high prevalence of cross-reactivity between the 2. Knowles SR, Shapiro LE, Shear NH. Anticonvulsant diVerent aromatic anticonvulsants , which in some hypersensitivity syndrome: incidence, prevention and reports is up to 80% and makes the choice of an management. Drug Saf 1999; 21: 489–501. alternative drug for these patients diYcult. Although 3. Sullivan JR, Sheal NH. The drug hypersensitivity syndrome. Arch Dermatol 2001; 137: 357–364. valproic acid, lamotrigine and vigabatrine are considered 4. Kleier RS, Breneman DL, Boiko S. Generalized pustulation the safest antiepileptic drugs for these patients, some as a manifestation of the anticonvulsant hypersensitivity cases of hypersensitivity anticonvulsant syndrome have syndrome. Arch Dermatol 1991; 127: 1361–1364. been reported to be triggered by them (1, 2). 5. HandŽ el-Jones SE, Jenkins RE, Whittaker SJ. The antiIn conclusion, we present an extremely unusual case convulsant hypersensitivity syndrome. Br J Dermatol 1993; of AHS, since both pustular exanthem and severe tubu129: 175–177. lointerstitial nephropathy are exceptional in the context 6. Lambert M, Fournier A. InsuYsance renale aigue compliquof this syndrome, especially if we consider their comant une hypersensibilite a la carbamazepine. Rev Neurol (Paris) 1992; 148: 574–576. bined appearance.