Altered Lipid Composition in a Non-differentiating Derivative of Streptomyces hygroscopicus

SUMMARY: The turimycin-producing Streptomyces hygroscopicus strain JA6599/NG60-93 (Tur+Amy+) and strain CC1, which is unable to produce antibiotic and aerial mycelium (Tur-Amy-), were compared with respect to their mycelial enzyme activities and cellular lipid composition. Changed activities of six enzymes of intermediary metabolism during submerged growth of strain CC1 on chemically defined medium attest to alterations of the life cycle. In addition, strain CC1 contained decreased amounts of 12-methyltetradecanoic acid in relation to 14-methylpentadecanoic acid (isopalmitic acid) and displayed a quantitatively altered phospholipid composition.