IL-10 reduces rat brain injury following focal stroke

Abstract The effects of the anti-inflammatory cytokine, IL-10, on brain injury following permanent focal ischemia were determined. Rats subjected to occlusion of the right middle cerebral artery (MCAO) were administered IL-10 (1 μ g) centrally into the lateral ventricle 30 min and 3 h post MCAO or systemically into the tail vein (5 or 15 μ g/h) starting 30 min post MCAO for 3 h. Brains were removed 24 h later and infarct size was measured. IL-10 administered centrally significantly ( P μ g/h significantly ( P