ОТДАЛЕННЫЕ РЕСПИРАТОРНЫЕ ПОСЛЕДСТВИЯ ЗАБОЛЕВАНИЙ ОРГАНОВ ДЫХАНИЯ, ВОЗНИКШИХ В НЕОНАТАЛЬНОМ ПЕРИОДЕ, У НЕДОНОШЕННЫХ ДЕТЕЙ

The study aims to determine the long-term outcomes of respiratory diseases that occurred in children during the neonatal period and to evaluate the contribution to the development of the adverse effects of the SOD2 genetic polymorphism (rs4880). Material and methods. A survey of 60 children with a history of bronchopulmonary dysplasia (BPD) and 60 children who had neonatal respiratory distress syndrome (RDS) without the development of BPD was conducted. It included the examination by a pulmonologist, a genetic study of venous blood, a chest multispiral computed tomography (MSCT), and the spirometry for the children over six years old. Results. As the outcome of the past BPD in older children, the formation of chronic lung diseases that occurred with the chronic obstructive pulmonary disease was significantly more frequently observed. Among the children in the comparison group, the clinical recovery was observed in the vast majority of patients. The function of external respiration in the children born prematurely reflected the presence of obstructive and restrictive ventilation disorders. The unevenness of pneumatization of the lung tissue and the areas of pneumofibrosis were more often detected during the MSCT study of the patients in the main group. The allelic variant of rs4880 C47T was more often detected in children of the main group, who formed chronic lung diseases as the outcome of BPD.