162 Drug–drug interaction predictions for MLN2480, an investigational pan-RAF inhibitor, based on nonclinical data

after anthracycline-based chemotherapy. AC induces lower levels of plasma miR-34a and doesn’t modify miR-122. The tumorectomy alone doesn’t deregulate miR-34a and miR-122. Circulating miR-34a and miR-122 are downregulated in NAC treated breast cancer patients compare to controls and normalized after treatments. Conclusion: This study demonstrates for the first time that NAC specifically induces expression of tumor suppressor miRNAs in plasma and tumor tissue that might be involved in the anti-tumor effect of the chemotherapy.