Design and Synthesis of 4'-ethyoxycombretastatin A-4

Design and synthesis of a novel Combertastatin A-4 analogue were carried out.Based on the synthesis of Combretastatin A-4,3,4,5-trimethoxybenzyltriphenylphosphonium and ethyoxyisovanilline were used as starting materials vis Wittig reaction to prepare 4'-ethyoxycombretastatin A-4.The structures of target compounds were confirmed by 1H NMR and melting point.The overall yields were about 62%.The synthetic routes developed herein required simple reaction conditions and few steps,and yield high stereoselectivity of cis-conformation.