Effect of Buxin Decoction on Content of B-type Natriuretic Peptide, Troponin I,Adenosine Triphosphate in Rats with Chronic Heart Failure after Myocardial Infarction

Objective:To observe the effect of Buxin decoction on the content of B-type natriuretic peptide(BNP),troponin I(TNI),adenosine triphosphate(ATP) in rats with heart failure after myocardial infarction.Method:Sixty rats were randomly divided into 6 groups:model group,sham-operation group,trimetazidine(TMZ) group low,middle and high dosage groups of Buxin decoction,10 rats in each group.The acute myocardial infarction(AMI) model was induced by ligation of the left anterior descending artery,oral administration lasted for 8 weeks.The BNP,TNI level was determined by enzyme-linked immuno sorbent assay(ELISA),and the contents of adenosine monophosphate(AMP),adenosine diphosphate(ADP) and ATP were measured by HPLC.Result:Before treatment,compared with the sham-operation group,BNP and TNI level in model and treated group significantly increased(P 0.01).After treatment,compared with model group,BNP and TNI level in Buxin decoction groups significantly decreased(P 0.01).Compared with the sham-operation group,the ATP content in model group was significantly lower(P 0.01).After the intervention of Buxin decoction,the ATP content increased in the high-dose and low dose group(P 0.05,P 0.01).Conclusion:Buxin decoction can reduce the content of BNP and TNI in rats with heart failure after myocardial infarction,and improve energy metabolism.