Coenzyme Q10 Therapy Blocks the Vicious Metabolic Cycle in Chronic Heart Failure

Background: Obstructive sleep apnea (OSA) is a well established risk of cardiovascular morbidity and mortality. The effect of OSA on EKG has not been well studied. The aim of our study is to investigate the impact of continuous positive airway pressure (CPAP) on EKG in patients with significant OSA. Methodology: We conducted a retrospective study using the sleep lab database in our academic center. 700 patients with OSA were randomly selected, of which 243 patients had moderate or severe OSA and prescribed CPAP, 337 patients had mild OSA, and 120 had normal study. Using T test we compared different EKG parameters in patients with moderate or severe OSA before and 6 to 12 months after the initiation of the CPAP treatment. From the 243 patients, 148 have documentation of CPAP compliance. The rest of the patients with no or questionable compliance were excluded. Results: Mean PR interval has dropped significantly in the study group from (123.34624.95) before CPAP treatment to (85.46640.99) after being complaint with the CPAP treatment for 6 to 12 months (p5 0.01). Similar trend was noticed in the QRS and QTc durations, but without being statistically significant. When comparing other EKG parameters, there was no statistically significant difference. Conclusion: CPAP treatment was associated with significant reduction is the PR interval duration in patients with moderate to severe OSA compliant with the treatment. The rest of the parameters were not statistically significant. A larger sample size is needed to confirm other relations observed in the study population. 067