Application of Stripping Voltammetry to the Determination of Guanethidine

Adsorptive stripping voltammetry for the determination of guanethidine is employed. The drug is adsorbed onto the hanging mercury drop electrode, and the reduction current of the accumulated drug is measured by scanning the potential in the cathodic direction. The adsorption and redox behaviour are explored by cyclic voltammetry. Optimum experimental conditions include preconcentration potential, solution pH, potential scan rate, and preconcentration time. A detection limit of guanethidine of 0.992 ng/cm3 was obtained.