Bone and joint bacterial infections in patients with rheumatoid arthritis

2020 
Abstract Bone tissue infections such as septic arthritis are some of the worst complications of orthopedic surgery in general, and arthroplasty in particular. They can be caused by almost any organism, but bacteria that form a biofilm are the most frequent and insidious in prosthetic joint infections (PJIs). The frequent bone infections of patients with rheumatoid arthritis (RA) may be related to the underlying disease (immunological dysfunction, immobility, disability, joint surgery), extra-articular factors, or disease-modifying antirheumatic drugs (DMARDs), immunosuppressants, and steroids. The use of biological drugs leads to the development of serious infections including tuberculosis. Patients should be informed of the increased risk of bone infections, and physicians need to be aware of how to treat them.
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