Amide derivatives or salts thereof referred.
1998
An amide derivative of formula (I) or a salt thereof: wherein ring B is an optionally fused heteroaryl group selected from imidazothiazol groups, tioxotiazol, tetrahydrobenzothiazol, tetrahydroquinolinyl, quinolyl, isoquinolyl, quinazolinyl, quinolidinyl, quinoxalinyl, cinnolinyl, benzimidazolyl, imidazopyridyl, benzoisoxazolyl, benzoxazolyl, benzothiazolyl, oxazolopyridyl, isothiazolopyridyl, pyrrolyl, imidazolyl, thiazolyl, pyrazolyl, isothiazolyl, isoxazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, thiadiazolyl, triazolyl, tetrazolyl, naphthyridinyl and pyridopyrimidinyl; said heteroaryl group may be substituted with at least one substituent selected from halogens and C1-C6 alkyl, C2-C6 alkenyl, C2-C6, hydroxy, sulfanyl, halogeno-C1-C6 alkyl, C1-C6-O-, C1-C6 alkyl-S-, C1-C6 alkyl-O-CO-, carboxy, sulfonyl, sulfinyl, C1-C6-SO-, C1-C6alkyl-SO2-, C1-C6 alkyl-CO-, C1 C6-CO-O-, carbamoyl, C1-C6-NH-CO-, di-C1-C6 alkyl-N-CO-, nitro, cyano, amino, C1-C6 alkyl NH-, di-C1 C6-N-, benzyl, halogenobenzyl, cyanobenzyl, nitrobenzyl, trifluoromethylbenzyl, isopropylbenzyl, phenylbenzyl, methoxycarbonylbenzyl, piperidincarbonilbencilo, benzyloxy, benzylsulfanyl, phenylamino, fluorophenylamino, phenylethyl, phenyl, naphthyl, quinolinyl, pyridylmethyl, guanidino, C1-C6-CO NH- and C1-C6 alkyl-SO2-NH-; X is a bond; C1-C6 alkenylene or C1-C6 alkylene group which may one be substituted by hydroxyl or a group C1-C6 alkyl; carbonyl; or -NH-; with the proviso that when X is a C1-C6 alkylene group optionally substituted with a group C1-C6, may form a ring together with the carbon atoms of ring B; A is methylene, ethylene or -CH2-O-; R1a and R1b are the same or different and are selected from H and C1-C6 alkyl groups; R2 is H or halogen; and Z is N or = CH-.
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