Pulmonary metastasectomy in colorectal cancer patients with previously resected liver metastasis: pooled analysis.

3553 Background: Data addressing the outcomes and patterns of recurrence following pulmonary metastasectomty (PM) in patients with colorectal cancer (CRC) and previously resected liver metastasis are very limited. Methods: We searched the PubMed for studies assessing PM in CRC and gathered individual data for patients who had PM and a previous curative liver resection. The influence of potential factors on overall survival (OS) was analyzed through univariate and multivariate analysis. Furthermore, the influence of patterns of recurrence following PM on post-recurrence survival was investigated. Results: Between 1983 and 2009, 146 patients from five studies underwent PM and had previous liver resection. The median interval from resection of liver metastasis until detection of lung metastasis and the median follow up from PM were 23 and 48 months respectively. Sixty seven (46%) underwent intra-operative thoracic lymph node (LN) sampling; nine of them (13%) had pathologically confirmed LN involvement, and 4...