Creutzfeldt-Jakob disease. The neuropathology of a transmission experiment.

Creutzfeldt-Jakob disease (CJD), together with its clinical variants, is the more common of the two subacute human spongiform encephalopathies, the other being kuru. The spongiform encephalopathies are slow infections caused by filterable self-replicating agents, the nature of which is not yet fully elucidated. The human diseases resemble three conditions of animals: scrapie of sheep and goats, transmissible mink encephalopathy, and wasting disease of mule deer and elk.