Enzymatic Resolution of cis- and trans-4-Hydroxycyclopent-2- enylmethanol Derivatives and a Novel Preparation of Carbocyclic 2′,3′- Dideoxydidehydronucleosides and Aristeromycin.

The (1R, 4S)-acetate 3 and the (1S, 4S)-alcohol 5 have been obtained optically pure by lipase catalysed esterification: compounds 3 and 5 have been converted into carbocyclic dideoxydidehydronucleosides and aristeromycin 9.