Wound-healing properties of copper nanoparticles as a function of physicochemical parameters

Results of a study on the wound-healing potential and physicochemical characteristics of copper nanoparticles prepared by high-temperature condensation and modified with a variety of agents (including oxygen, water vapors, and air) are reported. The modification of copper nanoparticles under monitored conditions guarantees the synthesis of particle species differing in size, phase composition, thickness, and composition of the oxide layer. Modified copper nanoparticles in the form of an ointment showed wound-healing behavior that differs in effectiveness depending on their physicochemical parameters. Nanoparticles of copper oxide (sample 7) (modified with air), with a particle size of 119 nm and crystalline copper content of ∼0.5%, and copper nanoparticles (sample 2) (modified with oxygen), with a particle size of 103 nm and crystalline copper content of 96%, demonstrated the maximum specific rate of wound adhesion.