Potentiometric Determination of Chlordiazepoxide Using PVC and Carbon Paste Electrodes

potentiometric technique is described for determination of chlordiazepoxide .A sensitive rapid ,simple method for evaluation of Chlordiazepoxide in pharmaceutical preparations and pure by using modified PVC and carbon paste electrodes is established. Chlordiazepoxide selective electrodes were produced as of chlordiazepoxide- phosphotungetic acid as an electroactive with n-Di-butyl phthalate(DBPH) in THF as a solvent. Various factors influencing the response of electrodes were improved and plotted the calibration curve . PVC and Carbon paste electrode constructed were gave a Nernstian response about 54.00, 57.51 mVdecade−1, respectively with an extensive range of concentration , from 3.0A—10-6-1.0A—10-2 and 1.8A—10-6-1.0A—10-2 M, for PVC, carbon paste electrode, respectively, with a little detection limit near to 2.2A—10-5, 1.4A—10-5M. The pH values for quantifiable was detected .Lastly, the projected electrode was used as effectively for the determination of chlordiazepoxide by potentiometric techniques in pure and pharmaceutical samples.