Abstract 16456: Cardiac Troponin Levels Do Not Change in Response to Exercise Stress Testing

Introduction: Exercise stress testing is commonly used to evaluate chest pain patients in the emergency department (ED). However, sensitivity is suboptimal, and the imaging component is both resource-intensive and may result in radiation exposure. A biomarker-based evaluation component for an exercise stress test would have several advantages. Hypothesis: We hypothesized that high-sensitivity troponin T (hsTnT) would increase from pre-exercise to post-exercise among patients undergoing exercise stress testing. We further hypothesized that these “stress-delta” values could differentiate patients with myocardial ischemia from those without. Methods: We prospectively collected demographic and clinical data, including stress test results, from 186 patients who presented to the ED with symptoms of acute coronary syndrome, had ruled out for myocardial infarction by serial contemporary TnT assays and electrocardiography, and were scheduled for exercise echocardiography. Plasma HsTnT (Roche Diagnostics) concentra...