Bromobenzofurans : a new class of potent, non-peptide antagonists of angiotensin II
1991
Abstract This paper describes the synthesis and pharmacology of a novel series of benzofurans which are antagonists of angiotensin II. One of these, the bromobenzofuran 11b , is a potent (apparent pK B =9.8) and specific antagonist of angiotensin II which, after oral administration (10mg/Kg), causes marked and long-lasting ( > 24h) falls in blood pressure in renal hypertensive rats.
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