ENDOTHELIN-INDUCED ACTIVATION OF CL- CHANNELS OF GUINEA PIG PARIETAL CELLS

: The addition of endothelin-1 to the bath solution dose-dependently increased the whole-cell Cl- currents in single parietal cells isolated from guinea pig stomach. NPPB dose-dependently inhibited the current. Endothelin-3 was also effective, though less than endothelin-1.