BLOOD UREA NITROGEN-TO-LEFT VENTRICULAR EJECTION FRACTION RATIO AS A PREDICTOR FOR CONTRAST INDUCED NEPHROPATHY IN ACUTE CORONARY SYNDROME PATIENTS WHO WERE TREATED WITH PERCUTANEOUS CORONARY INTERVENTIO

Background: Blood urea nitrogen (BUN) is an informative marker for both renal and cardiac performance in addition to the neurohormonal activity associated with their impairment. The aim of this study was to investigate the predictive value of the blood urea nitrogen-to-left ventricular ejection fraction ratio (BUN/EF) for the development of contrast induced nephropathy (CIN) in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). A total of 100 patients with ACS who were planning to attend PCI were enrolled in this observational study. The serum creatinine, BUN and LVEF were measured on the same day before contrast medium exposure. BUN/EF was determined for all patients. Serum creatinine was measured after PCI (48–72 hours) to detect development of CIN. Results: CIN had been developed in 14 cases (14%). Patients who developed CIN were older, had higher frequency of diabetes mellitus, higher frequency of hypertension and higher GENSINI Scores than those who had not develop CIN. BUN values were greater in the CIN group than those in the non-CIN one (22.8 ± 3 mg/dl vs 13.6±2.97 mg/dl, p