Hyperhomocysteinemia is a risk factor of recurrent coronary event in young patients irrespective to the MTHFR C677T polymorphism

Abstract Despite the well-known pro-coagulant effect of hyperhomocysteinemia, data is limited regarding the result on recurrent coronary event (RCE) in young people. One hundred and forty patients p  = 0.030], body mass index more than 25 [HR = 2.6; (95% CI, 1.1–5.9); p  = 0.034] and tHcy levels into quartile 4 (tHcy > 12.37 μmol/L) [HR = 2.5; (95% CI, 1.1–4.7); p  = 0.04]. Elevated plasma homocysteine level at admission is an independent risk factor for RCE after the first episode of ACS in young patients irrespective of the status of MTHFR C677T.