Pharmacokinetic-Pharmacodynamic Interactions Between Two Selective Monoamine Oxidase Inhibitors: Moclobemide and Selegiline

Summary:The objectives of this study were to assess potential pharmacokinetic and pharmacodynamic interactions between moclobemide and selegiline. Two groups of 12 healthy male and female subjects were treated with 200 mg moclobemide or 5 mg selegiline b.i.d. for 16 days. On study day 8, the alterna