Plasma 25-hydroxyvitamin D concentrations and risk of incident cancer in adults with hypertension: A nested case–control study

Summary Background & aims Evidence from epidemiologic studies on the association of circulating 25-hydroxyvitamin D [25(OH)D] concentrations with the incident risk of cancer has been inconsistent. We aimed to investigate the prospective relationship of baseline plasma 25(OH)D concentrations with the risk of cancer, and to examine possible effect modifiers. Methods We employed a nested case–control study design, including 231 patients with incident cancer during a median 4.5 years of follow up, and 231 matched controls from the China Stroke Primary Prevention Trial (CSPPT). Results The prevalence of plasma 25(OH)D  Conclusions Low plasma 25(OH)D concentrations (