Low dose prophylaxis in Tunisian children with haemophilia.

Introduction Low dose prophylaxis could be recommended in countries with limited resources. Aim We report our single centre experience in children with haemophilia. Patients Fifty-five children were included in our study with a weekly median dose of 30 UI kg−1 given once, twice or thrice a week. Age of initiation of prophylaxis is 5.32 years (0.64–11.44). Outcome assessment used were number of bleeding before and after initiating prophylaxis, haemophilia joint health score (HJHS), functional independence score in haemophilia (FISH) and quality of life with the Haemo-QoL. Results Reduction of number of bleeding was clear in all patients; HJHS, FISH and Haemo-QOL were satisfactory. Conclusion Low dose prophylaxis is effective and better than on-demand therapy. It should be the starting point for prophylaxis in countries with limited resources.