Palladium-Catalyzed C(sp3)—H Arylation of N-Boc Benzylalkylamines via a Deprotonative Cross-Coupling Process.

The first direct α-arylation of N-Boc benzylalkylamines is developed using aryl halides or triflate as electrophiles in the presence of a Pd/NiXantPhos catalyst system.