Genetic interaction analysis of VEGF-A rs3025039 and VEGFR-2 rs2071559 identifies a genetic profile at higher risk to develop nodular goiter

Angelo Molinaro,Paola Orlandi,Filippo Niccolai,Patrizia Agretti,G De Marco,E. Ferrarini,C. Di Cosmo,Paolo Vitti,Paolo Piaggi,T. Di Desidero,Guido Bocci,Massimo Tonacchera

Genetic interaction analysis of VEGF-A rs3025039 and VEGFR-2 rs2071559 identifies a genetic profile at higher risk to develop nodular goiter

2019

Angelo Molinaro
Paola Orlandi
Filippo Niccolai
Patrizia Agretti
G De Marco
E. Ferrarini
C. Di Cosmo
Paolo Vitti
Paolo Piaggi
T. Di Desidero
Guido Bocci
Massimo Tonacchera

Context Nodular goiter in patients from areas of iodine deficiency is due to the growth of follicular and endothelial cells, involving different vascular-related growth factors in its pathogenesis.

Keywords:

Genetic profile
Follicular phase
Endocrinology
VEGF receptors
Physiology
Internal medicine
Iodine deficiency
Diabetes mellitus
Pathogenesis
Goiter
Medicine
Cancer research
genetic interaction

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