First search for short-baseline neutrino oscillations at HFIR with PROSPECT.

This Letter reports the first scientific results from the observation of antineutrinos emitted by fission products of $^{235}$U at the High Flux Isotope Reactor. PROSPECT, the Precision Reactor Oscillation and Spectrum Experiment, consists of a segmented 4 ton 6Li-doped liquid scintillator detector covering a baseline range of 7-9 m from the reactor and operating under less than 1 meter water equivalent overburden. Data collected during 33 days of reactor operation at a nominal power of 85 MW yields a detection of 24608 $\pm$ 277 (stat.) inverse beta decays. Observation of reactor antineutrinos can be achieved in PROSPECT at 5{\sigma} statistical significance within two hours of on-surface reactor-on data-taking. A reactor-model-independent analysis of the inverse beta decay positron energy spectrum as a function of baseline sets new limits on neutrino oscillations in the high (>1eV$^2$) $\Delta$m$^2$ regime, and disfavors the best fit of the Reactor Antineutrino Anomaly at $>$95% confidence level.