On the interaction of non-thermal atmospheric pressure plasma with tissues

Non-thermal atmospheric pressure plasma is now being widely developed for various clinical applications such as skin sterilization, blood coagulation, cancer treatment, angiogenesis and wound healing among others. However, understanding of mechanism of interaction between non-thermal plasma and mammalian cells is lacking. Here we investigated the possibility that the dose of non-thermal plasma can be tuned to achieve various results depending on the clinical applications ranging from enhanced cell proliferation to inducing apoptosis in malignant tissue. We also present some of the underlying mechanisms of interaction of non-thermal plasma with mammalian cells.