Results of testing of highly mineralized products in clinical practice

Backgrounds. Development and testing of new methods of detoxification and anti-inflammatory therapy are important tasks of modern medicine in view of the continuous spread of diseases accompanied by persistent inflammatory reaction and/or accumulation in the body of toxic compounds, and the lack of effectiveness of currently used anti-inflammatory and anti-inflammatory treatments. Aim of the study: to study the clinical efficacy and safety by the dynamics of disease symptoms and some laboratory biochemical parameters of original highly mineralized products for external use in inflammatory human diseases. Materials and methods. An uncontrolled pilot study was conducted to investigate the efficacy and safety of highly mineralized products according to the most promising indications to determine appropriate directions for further controlled clinical trials. We recruited 3 patient groups of 10 people each. The first group received compressed wipes highly mineralized in the form of applications to the skin around arthritic joints. In the second group, compression bandages highly mineralized in the form of extensive and prolonged cutaneous applications in the trunk and extremities for detoxification in patients with chronic renal failure were used. The third group received a universal spray highly mineralized to eliminate the manifestations of skin itching in the form of aerosol spraying. Control was performed on the subjective feelings of patients using a visual analogue scale of pain and itching, clinical examination data and the dynamics of some laboratory biochemical parameters such as serum concentration of creatinine, urea, uric acid. Statistical analysis of the results was performed by structural and comparative analysis methods. Results and discussion. Complete remission of arthritis symptoms after a 10-day course of therapy was achieved in 50% of cases, and other patients showed significant improvement. On a visual analog scale, all patients experienced a decrease in pain intensity of at least 50% during the first 3-4 local napkin compression applications. Results of pilot tests of highly mineralized compression bandages in patients with chronic renal failure indicate some improvement in well-being and a slight decrease in serum concentrations of creatinine and uric acid by 10-30% in the subgroup of patients with initial serum kreatinine concentration to 200 µmol/l. The highly mineralized universal spray provides rapid (within a few seconds to 2 minutes) and complete or almost complete elimination of itching sensations at the site of application for 1 to 12 hours in all patients, regardless of the origin of the itching, but depending on its intensity. Conclusions. Original highly mineralized products are potentially effective and safe to use in the specified pathology according to the approved application protocols. There is a need for further controlled research in the outlined areas.