Pathomorphological changes in the cerebellum in rat chlamydial infection

Chlamydiosis of farm animals is a large group of diseases united etiologically. They differ in the nature of the course of the infectious process and the forms of its clinical manifestations. Often, chlamydiosis of pets shows neurological symptoms.Thus, the study of hemato-encephalic barrier passability by experimental chlamydiosis is of some interest. The final brain hemispheric tissues from rats experimentally infected with the chlamydiosis agent of the Laurie strain were chosen as the subject of the studies. The results of studies have shown that chlamydia disrupt the barrier functions of endothelium. Endothelial cells within blood vessels form a semipermeable barrier between the contents of the vessels and the tissues surrounding them. When examining the vascular channel in the control group of rats, it was clearly observed that endothelial cells fit closely together and interact poorly with cells circulating in the blood. The presence of chlamydia in capillary wall in rats infected with the agent results in endothelial cell hypertrophy. As a result, some of the endotheliocytes flow into the lumen of the vessels and break down and contribute to the generalization of infection. As a consequence of this process, changes in dyscirculatory character were observed primarily in gray and white matter and the soft cerebral membrane of the cerebellum with vascular channel damage. Consequently, the pathomorphological changes that occur in the brain substance in experimental chlamydia infection can be regarded as secondary ones that arise in response to circulatory disorders.