Rare-earth doped nanocomposites enable multiscale targeted short-wave infrared imaging of metastatic breast cancer
2017
We are investigating the ability of targeted rare earth (RE) doped nanocomposites to detect and track micrometastatic
breast cancer lesions to distant sites in pre-clinical in vivo models. Functionalizing RE nanocomposites with AMD3100
promotes targeting to CXCR4, a recognized marker for highly metastatic disease. Mice were inoculated with SCP-28
(CXCR4 positive) and 4175 (CXCR4 negative) cell lines. Whole animal in vivo SWIR fluorescence imaging was
performed after bioluminescence imaging confirmed tumor burden in the lungs. Line-scanning confocal fluorescence
microscopy provided high-resolution imaging of RE nanocomposite uptake and native tissue autofluorescence in ex vivo
lung specimens. Co-registered optical coherence tomography imaging allowed assessment of tissue microarchitecture.
In conclusion, multiscale optical molecular imaging can be performed in pre-clinical models of metastatic breast cancer,
using targeted RE-doped nanocomposites.
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