[Cytokine responses after lobectomy for early non-small cell lung cancer: a prospective randomized comparison of video-assisted thoracic surgery and open thoracotomy].

Objective To compare video-assisted thoracic surgery (VATS) and open thoracotomy (OT) on acute inflammatory responses and immunosuppression after lobectomy for early non-small cell lung cancer (NSCLC). Methods Present prospective randomized study. OT or VATS lobectomy was performed in patients who met enter criteria and clinical data was collected. Plasma concentration of IL-6, IL-8 and IL10 were measured before surgery and at postoperative day (POD) 1 and POD 3. There were 271 patients underwent lobectomy for early NSCLC, including of 133 patients in group VATS and 138 patients in group OT from January 2007 to June 2008. There were 132 males and 139 females, aging from 19 ～70 years with a mean of ( 56 ± 8) years. Results Compared with OT group, shorter postoperative hospital stay [ ( 8.2 ±2.5) dvs. (9.8±6.2) d, P=0.03], lower morbidity rate (11.3% vs. 21.7%, P=0.02) and lower increase of plasma concentration of IL-6 at POD 1 [ ( 35 ± 25 ) % vs. (65 ± 43 ) %, P = 0.00 ], IL-6 at POD 3 [(14±22)% vs. (55±44)%,P=0.00] and IL-10 at POD 1 [(25 ±20)% vs. (43±35)%, P=0.00] were observed in patients of VATS group. Conclusion VATS lobectomy for early NSCLC is associated with less acute inflammatory responses and less immunosuppression when compared with OT. Key words: Carcinoma,non-small-cell lung; Thoracoscopy; Pneumonectomy; Interleukins