Morphea patients with mucocutaneous involvement: A cross sectional study from the Morphea in Adults and Children (MAC) cohort.

BACKGROUND Demographic and clinical findings of patients with mucocutaneous morphea have not been well characterized. OBJECTIVE To determine the demographic and clinical characteristics of morphea patients with mucocutaneous lesions enrolled in the Morphea in Adults and Children Cohort (MAC). METHODS Cross-sectional study of 735 patients in the MAC Cohort from 2007 to 2018. RESULTS 4.6% of linear morphea patients had oral involvement versus 2.4% among the entire cohort while 10.3% of generalized morphea patients had genital involvement versus 3.7% among the entire cohort. Those with genital lesions had an older age of disease onset than oral morphea (57 versus 11.5 years old; p<0.001) and more frequent extragenital lichen sclerosus atrophicus (LSA) (59.2% versus 5.6%; p=0.004). LIMITATIONS Selection bias and limited number of affected subjects. CONCLUSION Oral morphea lesions predominate in younger patients with facial linear morphea while genital lesions predominate in post-menopausal women with overlying extragenital LSA.