Single Water Molecule Recognition: A 1:1 Complex of Crownophane with Water by Pseudo-tetrahedral Hydrogen Bond Formation

A 22-membered crownophane prepared via the “Tandem Claisen Rearrangement” was found to form stable 1:1 complex with water, which is incorporated into the cavity by pseudo-tetrahedral hydrogen bond formation and observed by DSC, TGA, and X-ray structural analysis.