Генетический полиморфизм тромбофилии у пациентов с тромбоэмболией легочной артерии в Приморском крае

The paper analyses genetic polymorphism of thrombophilia in 68 patients with thromboembolia of the pulmonary artery (PATE) in Pimorsky Krai. The polymorphisms in genes associated with the risk factors for thrombophilia and venous thromboembolic complications was somewhat distinctive in comparison with that of the European population, and, foremost, it was represented by mutations in genes of folate cycle (97.1 % of cases) and disorders related to plasminogen activator inhibitor type 1 gene (88.2 % of cases). The genetic predisposition to hyperaggregation of platelets was recorded in more than half of the patients (55.9 %). The synergism of thrombosis risk factors was observed in all PATE cases. These changes shall be allowed for when developing programs for secondary prevention of venous thromboembolic complications. The therapy shall be continuous and likely to last throughout the life, and include drugs known to have effect on different coagulation system components, based upon both laboratory findings that are indicative of haemostatic disorders, and foremost, molecular genetic testing results.