Distribution and antibiotic resistance analysis of the Acinetobacter baumannii strains in sterile body fluids

2013 
Objective To investigate the distribution and antimicrobial resistance pattern of Acinetobacter baumannii in sterile body fluids for rational use of antimicrobial agents.Methods A retrospective review was conducted to analyze the A.baumannii strains in sterile body fluids from September 2011 to August 2012in the Second Affiliated Hospital of Nanchang University in terms of clinical department,patient age,specimen source and drug resistance.Antimicrobial susceptibility testing was carried out by Kirby-Bauer method.The results were interpreted according to the breakpoints of CLSI 2011.All data were analyzed with WHONET5.5 software.Results A total of 88 A.baumannii strains were isolated from sterile body fluids,56(63.6%) of which were collected from the patients in intensive care unit(ICU),55(62.5%)strains from the elderly patients(50 years of age or older),and 54(61.4%)strains were isolated from blood samples.The prevalence of multi-drug resistant A.baumannii was 81.8%.More than 75.0%of these A.baumannii isolates were resistant to seven of the 12 antimicrobial agents tested,but the least resistant to cefoperazone-sulbactam(21.6%).Conclusions Compromised immune function is the major cause for A.baumannii infection.It is a serious issue to isolate multidrug resistant A.baumannii from sterile body fluids.It is reasonable to consider cefoperazone-sulbactam as one of the options in empirical treatment.
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