Carbocyclic analogues of hydroxyethylamine containing inhibitors of HIV proteinase
1994
The cyclohexane analogues 3 and 4 of the piperidine carboxamide 1 have been synthesized. The trans isomer 3 is more potent than the hydroxyethylamine 1versus HIV-1 proteinase, while the cis isomer 4 is less potent.
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