Process for the preparation of compounds with a fused pyridine ring.

PREPARING 2-amino-4-hydroxy-6 [2- (4-carboxyphenyl) alk-1-EN-YL] pyrido [2,3-d] pyrimidines and 2-amino-4-hydroxy-6 [2- ( 4-carboxyphenyl) alk-1-IN-YL] pyrido [2,3-d] pyrimidines THROUGH reacting a compound haloaromatic AND UNSATURATED COMPOUNDS IN THE PRESENCE OF pALLADIUM CATALYST. CHEMICAL PRODUCTS ARE INTERMEDIATE FOR PRODUCING antineoplastic agents. A typical addition is the reaction of a 2-AMINO-4-HYDROXY-6-ETINILPIRIDO [2,3-d] pyrimidine and an ester of 4-iodobenzoic acid.