Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells

Abstract A focused library of variously substituted 9-aminoacridine compounds was screened for bioactivity against accumulation of the infectious prion protein isoform, denoted PrP Sc , in a cell model of prion replication. The efficacy of compounds against PrP Sc accumulation was influenced by both substituents of the distal tertiary amine and acridine heterocycle, while cellular cytotoxicity was encoded in the acridine heterocycle substituents.