Spectral and photophysical properties of cytisine in acetonitrile – Theory and experiment
2018
Abstract Spectral and photophysical properties of (−)-cytisine that is used as a smoking cessation aid, and which derivatives are promising tools in a treatment of neurological diseases, were investigated in acetonitrile, non-specifically interacting solvent with a polarity similar to water. The two chair conformers of cytisine were found the most stable in the ground state S 0 and the lowest excited singlet state S 1 (π,π*), wherein axial one was characterized by a significantly larger abundance, fluorescence lifetime 0.15 ns and fluorescence quantum yield 0.008. The S 1 (π,π*) excited state of both cytisine conformers deactivated almost exclusively via internal conversion.
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