Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass Intensity (PMI) and CO Generated versus the Batch–Batch Process

Douglas A. L. Otte,Kallol Basu,Lisa Jellett,Michael Whittington,Glenn Spencer,Matthew Burris,Emily B. Corcoran,Kevin Stone,Jarod Nappi,Rebecca A. Arvary,David Donoghue,Hong Ren,Kevin M. Maloney,John R. Naber

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass Intensity (PMI) and CO Generated versus the Batch–Batch Process

2020

Douglas A. L. Otte
Kallol Basu
Lisa Jellett
Michael Whittington
Glenn Spencer
Matthew Burris
Emily B. Corcoran
Kevin Stone
Jarod Nappi
Rebecca A. Arvary
David Donoghue
Hong Ren
Kevin M. Maloney
John R. Naber

Gefapixant citrate (MK-7264) is a P2X3 antagonist for the treatment of chronic cough. The second generation manufacturing route developed for the Step 3A/3B formylation–cyclization reaction to gene...

Keywords:

Green chemistry
Work in process
Formylation
Flow chemistry
Pulp and paper industry
Batch processing
Chemistry
sustainable manufacturing

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