Adaptive optics OCT with a non-modulated pyramid wavefront sensor

An adaptive optics optical coherence tomography (AO-OCT) system with a non-modulated pyramid wavefront sensor (P-WFS) is presented. The P-WFS is implemented as add-on to a Shack Hartmann (SH) WFS based AO-OCT system, where the AO loop is driven by either sensor. Equivalent performance of the AO-OCT is demonstrated with the P-WFS and the SH-WFS by visualizing the mosaics of different retinal cell types in image data obtained in-vivo at the fovea of a healthy volunteer. Contrary to the SH-WFS, the pupil sampling of P-WFS is flexible and may be adjusted in order to further increase the sensitivity of the sensor.