Effect of internal carotid artery infusion of propofol on neurovascular tissues of cerebral infusion areas in rats

Objective To explore the security of propofol used in internal carotid artery anesthesia by observing the effect of internal carotid artery infusion of propofol on neurovascular tissue of cerebral infusion areas in rats.Methods A total of 40 SD rats were randomly divided into a V group and an A group (n=20); rats in the V group were given treatment of right femoral vein infusion of 30 mg/ (kg· h) propofol,and those in the A group were given treatment of right internal carotid artery infusion of 30 mg/(kg· h) propofol for 3 h.Rats were sacrificed 4 h after propofol withdrawal.HE staining and transmission electron microscopy were employed to detect the morphological and ultrastructural changes in the right cerebral cortex tissues; and semi-quantitative real time PCR was used to observe the mRNA expressions of bcl-2 and Bax.Results No obvious acute injury was noted in both groups,and the morphology of cortical neurons,neuralgia cells and vascular structures was normal in both groups.And the neuronal nuclei,organelles and capillary endomembrane of both groups were normal,without obvious changes.No significant difference in mRNA expressions ofbcl-2 and Bax was noted between the two groups (P＞0.05).Conclusion It is insignificant in the effects of internal carotid artery infusion of propofol on neurovascular tissues of cerebral infusion areas in rats. Key words: Propofol;  Internal carotid artery;  Anesthesia;  Cerebrum;  Bispectral index