Self-catalytic techniques for the synthesis of biologically relevant heterocyclic scaffolds at room temperature: a recent update

Abstract As a part of green chemistry advancements, particularly in the field of synthetic organic chemistry, the concept of self-catalytic synthesis has recently emerged. Accordingly, the last decade has seen an ongoing development in designing organic synthetic protocols without the aid of any added catalysts. Catalyst-free synthetic processes have manifolds of benefits so as to get rid of toxicity and wastes associated with using these catalysts. Hence, designing of catalyst-free synthetic processes is a step forward toward safe, cost-effective, waste-free, simple, and sustainable environment. The present book chapter focuses on the recent update in the area of catalyst-free syntheses of heterocycles of biological interest at room temperature, reported since 2017.