Milieux hyperbasiques: Recherches sur les amides et lactames ω-halogénés. Essais de cyclisation

Linear halogenated N,N-disubstituted amides afford cyclic amides in good yields by reaction with 'activated' lithium dialkylamides. However, the same reaction with substituted amides gives mainly ω-ethylenic amides.In the same way, N-substituted γ- and δ-lactams with an ω-halogenated chain in the α position afford pure spirolactams whereas the reaction of e-Iactams furnishes a mixture of spiro and ethylenic compounds.