La expresión de P53 y C-erb-2 en el carcinoma de células transicionales de pelvis y uréter y su relación con progresión tumoral y supervivencia

OBJECTIVE: to evaluate P 53 and c-erb-2 overexpression as a prognostic factor for progression and survival in patients with renal pelvis and ureter tumors. METHODS: Retrospective review of the medical records and pathology/immunohistochemical reports of 61 patients who underwent surgery for upper urinary tract urothelial tumors. Immunohistochemical studies were performed using the STREPTAVIDIN-BIOTIN-PEROXIDASE techniques with a LASAB kit (DAKO). Pearson's Chi square for 2x2 contingence tables and residues analysis were used for non continuous variables, with a confidence level of p<0.05. COX multivariate analysis and survival curves were used for multiple variables association. RESULTS: A higher P 53 overexpression was related with tumour dependant death (p<0.001) These patients have their long term survival compromised. C-erb-2 overexpression is not statistically related to either proliferation or cancer specific death in upper urinary tract urothelial tumors. CONCLUSIONS: In our series P53 overexpression has prognostic value in upper urinary tract urothelial tumors, but c-erb-2 did has not prognostic value.